HEPATOTROPIC EFFECTS OF TRIPLE ANTIULCER THERAPY AND PLACENTA CRYOEXTRACT: THE ROLE OF SEX FACTORS IN LIPOPEROXIDATION

The purpose of the work was to reveal role sex factors in processes lipid peroxidation (LPO) against background chronic ethanol-tetrachloromethane-induced liver damage and hepatotropic effects triple antiulcer therapy cryopreserved placenta extract (CEP). Chronic induced by introduction a CCl4 solution combination with an ethanol for 45 days. content reactants thiobarbituric acid (TBA-active products) catalase activity were measured homogenates. Modulation hormones achieved surgical ovariectomy or testectomy. study showed that combined intravenous administration esomeprazole, clarithromycin metronidazole rats caused inhibition antioxidant defense system, this indicated statistically significant decrease 38.4% antioxidant-prooxidant index 35.1%, compared parameters intact rats. most activation LPO noted females ethanol-tetrachloromethaneinduced anti-ulcer drugs after ovariectomy. In case, TBAactive products 36.1 ± 2.79 ?mol/kg tissue. It established castrated females, use CEP leveled processes, (P < 0.001) 2.7 times lower TBA-active